

| Número de catálogo | HX187014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Descripción |
Anti-Human DEFA5 Polyclonal Antibody (HX187014) is a rabbit polyclonal antibody detecting DEFA5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactividad de especies | Human | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human DEFA5 (Glu20-Arg94). | ||||||||
| Objetivo | HD5(20-94), DEF5, Defensin-5, DEFA5, Defensin, alpha 5 | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | Q01523 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Fondo | Defensin alpha 5 (DEFA5) is a ~10 kDa protein. Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. 1. Ghosh, D. et al. (2002) Nature immunology 3, 583-90. PMID: 12021776 2. Salzman, NH. et al. (2003) Nature 422, 522-6. PMID: 12660734 3. Ericksen, B. et al. (2005) Antimicrobial agents and chemotherapy 49, 269-75. PMID: 15616305 4. de Leeuw, E. et al. (2009) FEBS letters 583, 2507-12. PMID: 19589339 5. Spencer, JD. et al. (2012) PloS one 7, e31712. PMID: 22359618 6. Rajabi, M. et al. (2012) The Journal of biological chemistry 287, 21615-27. PMID: 22573326 7. Schroeder, BO. et al. (2015) Mucosal immunology 8, 661-71. PMID: 25354318 8. Wang, C. et al. (2015) Journal of medicinal chemistry 58, 3083-93. PMID: 25782105 9. Ehmann, D. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 3746-3751. PMID: 30808760 | ||||||||
| Nota | For research use only. |



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