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| カタログ番号 | HT380014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human DEFB4A Polyclonal Antibody (HT380014) is a rabbit polyclonal antibody detecting DEFB4A. Suitable for Human.
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DEFB4A (Gly24-Pro64). | ||||||||
| ターゲット | BD-2, Beta-defensin 2, DEFB102, DEFB2, DEFB4, DEFB4A, Defensin beta 4A, Defensin, beta 2, SAP1, Skin-antimicrobial peptide 1, hBD-2 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15263 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Defensin beta 4A (DEFB4A) is a ~7 kDa protein. Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria, with highest activity against Gram-negative bacteria. Antimicrobial activity against P.aruginosa seems to be salt-sensitive and is reduced with high salt concentrations greater than 25 mM. Also exhibits antimicrobial activity against the yeast C.albicans. Permeabilizes C.albicans cell membranes via targeting plasma membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2), thereby leading to cell fragmentation and cell death. Acts as a ligand for C-C chemokine receptor CCR6. 1. Harder, J. et al. (2000) American journal of respiratory cell and molecular biology 22, 714-21. PMID: 10837369 2. Harder, J. et al. (1997) Nature 387, 861. PMID: 9202117 3. Järvå, M. et al. (2018) Science advances 4, eaat0979. PMID: 30050988 4. Yang, D. et al. (1999) Science (New York, N.Y.) 286, 525-8. PMID: 10521347 5. Röhrl, J. et al. (2010) The Journal of biological chemistry 285, 7028-34. PMID: 20068036 | ||||||||
| 注意事項 | For research use only |
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