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| カタログ番号 | HT320014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human DENR Polyclonal Antibody (HT320014) is a rabbit polyclonal antibody detecting DENR/Drp1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DENR (Lys114-Lys198). | ||||||||
| ターゲット | SMAP-3, Smooth muscle cell-associated protein 3, DRP, DRP1, DENR, Protein DRP1, Density-regulated protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43583 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Density-regulated protein (DENR/Drp1) is a ~22 kDa protein. Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-DENR polyclonal antibody at 1ug/mL on various samples.
Lane 1: NIH3T3 cell lysate
Lane 2: 293T cell lysate
Lane 3: Mouse brain lysate
Lane 4: Rat brain lysate
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