

| Каталожный номер | HD575014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human DHRS11 Polyclonal Antibody (HD575014) is a rabbit polyclonal antibody detecting DHRS11. Suitable for Mouse and Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human DHRS11 (Leu31-Thr260). | ||||||||
| Цель | 17-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid 3-dehydrogenase, DHRS11, Dehydrogenase/reductase SDR family member 11, EC:1.1.1.270, EC:1.1.1.62, Estradiol 17-beta-dehydrogenase, SDR24C1, Short-chain dehydrogenase/reductase family 24C member 1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q6UWP2 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Dehydrogenase/reductase SDR family member 11 (DHRS11) is a ~28 kDa protein. Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. 1. Endo, S. et al. (2016) Biochemical and biophysical research communications 472, 231-6. PMID: 26920053 2. Endo, S. et al. (2020) The Journal of steroid biochemistry and molecular biology 199, 105586. PMID: 31926269 | ||||||||
| Примечание | For research use only |
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