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| カタログ番号 | HT458014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DHX15 (Asp568-Tyr795). | ||||||||
| ターゲット | DDX15, DEAH box protein 15, Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15, DHX15, DBP1, ATP-dependent RNA helicase #46 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O43143 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-dependent RNA helicase DHX15 is a ~90 kDa protein. RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3). 1. Yoshimoto, R. et al. (2009) Nucleic acids research 37, 891-902. PMID: 19103666 2. Lin, ML. et al. (2009) Cancer science 100, 1443-50. PMID: 19432882 3. Mosallanejad, K. et al. (2014) Science signaling 7, ra40. PMID: 24782566 4. Lu, H. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 1364-72. PMID: 24990078 5. Studer, MK. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 7159-7170. PMID: 32179686 6. Xing, J. et al. (2021) Cell reports 35, 109205. PMID: 34161762 | ||||||||
| 注意事項 | For research use only. |
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