Anti-Human DHX15 Polyclonal Antibody (HT458014)

Name: Anti-Human DHX15 Polyclonal Antibody
Brand: abinScience
SKU: HT458014
Price: 168 USD
Availability: InStock

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HT458014

Реактивность видов

Human, Mouse

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human DHX15 (Asp568-Tyr795).

Цель

DDX15, DEAH box protein 15, Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15, DHX15, DBP1, ATP-dependent RNA helicase #46

Очистка

Purified by antigen affinity column.

Номер доступа

O43143

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

ATP-dependent RNA helicase DHX15 is a ~90 kDa protein. RNA helicase involved in mRNA processing and antiviral innate immunity. Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome. Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3).

1. Yoshimoto, R. et al. (2009) Nucleic acids research 37, 891-902. PMID: 19103666

2. Lin, ML. et al. (2009) Cancer science 100, 1443-50. PMID: 19432882

3. Mosallanejad, K. et al. (2014) Science signaling 7, ra40. PMID: 24782566

4. Lu, H. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 1364-72. PMID: 24990078

5. Studer, MK. et al. (2020) Proceedings of the National Academy of Sciences of the United States of America 117, 7159-7170. PMID: 32179686

6. Xing, J. et al. (2021) Cell reports 35, 109205. PMID: 34161762

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human DHX15 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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