

| Numéro de catalogue | HP806014 | ||||||||
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| Description |
Anti-Human DIO2 Polyclonal Antibody (HP806014) is a rabbit polyclonal antibody detecting DIO2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human DIO2 (Leu69-Leu269). | ||||||||
| Cible | DIO2, TXDI2, ITDI2, Type II iodothyronine deiodinase, Type-II 5'-deiodinase, Type 2 DI, 5DII, DIOII | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | Q92813 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Type II iodothyronine deiodinase (DIO2) is a ~30 kDa protein. Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3), 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine. 1. Curcio-Morelli, C. et al. (2003) Endocrinology 144, 937-46. PMID: 12586771 2. Buettner, C. et al. (2000) Endocrinology 141, 4606-12. PMID: 11108274 3. Salvatore, D. et al. (1999) Biochimie 81, 535-8. PMID: 10403186 4. Piehl, S. et al. (2008) Rapid communications in mass spectrometry : RCM 22, 3286-96. PMID: 18821722 5. Piehl, S. et al. (2008) Endocrinology 149, 3037-45. PMID: 18339710 | ||||||||
| Note | For research use only. |
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