Anti-Human Dkk-1 Recombinant Antibody (SAA1268) (HF914033)

Name: Anti-Human Dkk-1 Recombinant Antibody (SAA1268)
Brand: abinScience
SKU: HF914033
Price: 126 USD
Availability: InStock

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Precio(USD):

Especificación:

20ug
50ug
100ug
1mg

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HF914033

Reactividad de especies

Human

Aplicaciones

ELISA

Especie huésped

Human

Clonalidad

Monoclonal

Isotipo

VHH-hFc

ID de clon

SAA1268

Objetivo

Dickkopf-1, SK, hDkk-1, Dkk-1, Dickkopf-related protein 1, DKK1

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>90% as determined by SDS-PAGE.

Purificación

Protein A/G purified from cell culture supernatant.

Número de acceso

O94907

RRID

Anti-Human DKK1 Antibody (SAA1268) (abinScience Cat# HF914033, RRID:AB_3729854)

Forma

Liquid

Buffer de almacenamiento

0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:2000-1:20000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Dickkopf-related protein 1 (DKK1) is a ~28 kDa protein. Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity.

1. Ahn, VE. et al. (2011) Developmental cell 21, 862-73. PMID: 22000856

2. Niehrs, C. (2006) Oncogene 25, 7469-81. PMID: 17143291

Nota

For research use only.

Isotype Control

VHH-hFc (IgG1) Isotype Control antibody (cAb-Lys2) (ZP167307)

Imágenes