Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Name: Anti-Human DNAJB2 Polyclonal Antibody
Brand: abinScience
SKU: HB700014
Price: 96 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue

HB700014

Description

Anti-Human DNAJB2 Polyclonal Antibody (HB700014) is a rabbit polyclonal antibody detecting DNAJB2 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human DNAJB2 (Ala2-Gly91).

Cible

HSJ-1, Heat shock protein J1, DNAJB2, Heat shock 40 kDa protein 3, DnaJ homolog subfamily B member 2, HSPF3, HSJ1

Purification

Purified by antigen affinity column.

Numéro d'accès

P25686

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

DnaJ homolog subfamily B member 2 (DNAJB2) is a ~35 kDa protein. Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.

1. Gao, XC. et al. (2012) The Journal of biological chemistry 287, 6044-52. PMID: 22219199

2. Cheetham, ME. et al. (1994) European journal of biochemistry 226, 99-107. PMID: 7957263

3. Westhoff, B. et al. (2005) Current biology : CB 15, 1058-64. PMID: 15936278

4. Gao, XC. et al. (2011) PloS one 6, e19763. PMID: 21625540

5. Chapple, JP. et al. (2003) The Journal of biological chemistry 278, 19087-94. PMID: 12754272

6. Rose, JM. et al. (2011) Human molecular genetics 20, 16-27. PMID: 20889486

7. Meimaridou, E. et al. (2011) Molecular endocrinology (Baltimore, Md.) 25, 1650-60. PMID: 21719532

8. Labbadia, J. et al. (2012) Brain : a journal of neurology 135, 1180-96. PMID: 22396390

9. Novoselov, SS. et al. (2013) PloS one 8, e73944. PMID: 24023695

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human DNAJB2 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Aperçu

Images

Reférences

Fiche technique

SDS