Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

Name: Anti-Human DNAJB2 Polyclonal Antibody
Brand: abinScience
SKU: HB700014
Price: 96 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HB700014

説明

Anti-Human DNAJB2 Polyclonal Antibody (HB700014) is a rabbit polyclonal antibody detecting DNAJB2 in ELISA, IHC, WB. Suitable for Human, Mouse.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human DNAJB2 (Ala2-Gly91).

ターゲット

HSJ-1, Heat shock protein J1, DNAJB2, Heat shock 40 kDa protein 3, DnaJ homolog subfamily B member 2, HSPF3, HSJ1

精製

Purified by antigen affinity column.

アクセッション番号

P25686

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

DnaJ homolog subfamily B member 2 (DNAJB2) is a ~35 kDa protein. Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins.

1. Gao, XC. et al. (2012) The Journal of biological chemistry 287, 6044-52. PMID: 22219199

2. Cheetham, ME. et al. (1994) European journal of biochemistry 226, 99-107. PMID: 7957263

3. Westhoff, B. et al. (2005) Current biology : CB 15, 1058-64. PMID: 15936278

4. Gao, XC. et al. (2011) PloS one 6, e19763. PMID: 21625540

5. Chapple, JP. et al. (2003) The Journal of biological chemistry 278, 19087-94. PMID: 12754272

6. Rose, JM. et al. (2011) Human molecular genetics 20, 16-27. PMID: 20889486

7. Meimaridou, E. et al. (2011) Molecular endocrinology (Baltimore, Md.) 25, 1650-60. PMID: 21719532

8. Labbadia, J. et al. (2012) Brain : a journal of neurology 135, 1180-96. PMID: 22396390

9. Novoselov, SS. et al. (2013) PloS one 8, e73944. PMID: 24023695

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-Human DNAJB2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-Human DNAJB2 Polyclonal Antibody (HB700014)

概要

イメージ

参考文献

データシート

SDS