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| カタログ番号 | HF866014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DNAJB6 (Met1-Gly124). | ||||||||
| ターゲット | HHDJ1, Heat shock protein J2, MRJ, HSJ-2, HSJ2, MSJ-1, DnaJ homolog subfamily B member 6, DNAJB6, MSJ1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75190 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DnaJ homolog subfamily B member 6 (DNAJB6) is a ~36 kDa protein. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Also reduces cellular toxicity and caspase-3 activity. 1. Izawa, I. et al. (2000) The Journal of biological chemistry 275, 34521-7. PMID: 10954706 2. Tsai, PC. et al. (2017) Clinical genetics 92, 150-157. PMID: 28233300 3. Chuang, JZ. et al. (2002) The Journal of biological chemistry 277, 19831-8. PMID: 11896048 4. Sarparanta, J. et al. (2012) Nature genetics 44, 450-5, S1-2. PMID: 22366786 5. Hageman, J. et al. (2010) Molecular cell 37, 355-69. PMID: 20159555 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-DNAJB6 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Jurkat cell lysate
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