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| カタログ番号 | HP110014 | ||||||||
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| 説明 |
Anti-Human DNAJB9 Polyclonal Antibody (HP110014) is a rabbit polyclonal antibody detecting DNAJB9 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DNAJB9 (Ser24-Gln223). | ||||||||
| ターゲット | Microvascular endothelial differentiation gene 1 protein, ER-resident protein ERdj4, Endoplasmic reticulum DNA J domain-containing protein 4, Mdg-1, MDG1, DnaJ homolog subfamily B member 9, ERdj4, DNAJB9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9UBS3 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DnaJ homolog subfamily B member 9 (DNAJB9) is a ~25 kDa protein. Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins. In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1. Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production. 1. Dong, M. et al. (2008) Molecular biology of the cell 19, 2620-30. PMID: 18400946 | ||||||||
| 注意事項 | For research use only. |
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