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| カタログ番号 | HV184014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human DNAJC2 Polyclonal Antibody (HV184014) is a rabbit polyclonal antibody detecting DNAJC2. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DNAJC2 (Lys442-Lys621). | ||||||||
| ターゲット | DNAJC2, DnaJ homolog subfamily C member 2, DnaJ homolog subfamily C member 2, N-terminally processed, M-phase phosphoprotein 11, MPHOSPH11, MPP11, ZRF1, Zuotin-related factor 1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99543 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | DnaJ homolog subfamily C member 2 (DNAJC2) is a ~71 kDa protein. Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-DNAJC2 polyclonal antibody at 1ug/mL on various samples.
Lane 1: Caco2 cell lysate
Lane 2: HT-29 cell lysate
Lane 3: Hela cell lysate
Lane 4: HepG2 cell lysate
Lane 5: K562 cell lysate
Lane 6: PC-3 cell lysate
Lane 7: NIH3T3 cell lysate
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