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| カタログ番号 | HB924014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human DNMT1 Polyclonal Antibody (HB924014) is a rabbit polyclonal antibody detecting DNMT1 in ELISA, IHC, WB. Suitable for Bovine and Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DNMT1 (Arg730-Ile907). | ||||||||
| ターゲット | CXXC-type zinc finger protein 9, MCMT, AIM, DNMT1, DNA MTase HsaI, DNMT, DNA (cytosine-5)-methyltransferase 1, Dnmt1, DNA methyltransferase HsaI, M.HsaI, CXXC9 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P26358 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA (cytosine-5)-methyltransferase 1 (DNMT1) is a ~183 kDa protein. DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. 1. Schlesinger, Y. et al. (2007) Nature genetics 39, 232-6. PMID: 17200670 2. Pradhan, M. et al. (2008) Biochemistry 47, 10000-9. PMID: 18754681 3. Felle, M. et al. (2011) Nucleic acids research 39, 8355-65. PMID: 21745816 4. Zhang, ZM. et al. (2015) Journal of molecular biology 427, 2520-2531. PMID: 26070743 5. Viré, E. et al. (2006) Nature 439, 871-4. PMID: 16357870 8. Serra, RW. et al. (2014) eLife 3, e02313. PMID: 24623306 | ||||||||
| 注意事項 | For research use only. |
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