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| カタログ番号 | HW393013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ICC, IHC, WB | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a | ||||
| クローンID | N331/19 | ||||
| ターゲット | D(3) dopamine receptor, Dopamine D3 receptor, DRD3 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P35462 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | D(3) dopamine receptor (DRD3/Dopamine D3 receptor) is a ~44 kDa protein. Dopamine receptor that is primarily expressed in limbic areas of the brain and is involved in the modulation of cognitive, emotional, and endocrine functions. Plays a key role in regulating neuronal signaling pathways associated with motivation, reward, and behavior. Coupled to G(i)/G(o) proteins; activation leads to inhibition of adenylate cyclase and decreased intracellular cAMP levels. Involved in the control of locomotor activity and implicated in several neuropsychiatric disorders, including schizophrenia and substance use disorders. Promotes cell proliferation through MAP kinase signaling. 1. Osugo, M. et al. (2025) Nature communications 16, 1852. PMID: 39984436 2. Zaworski, PG. et al. (1999) British journal of pharmacology 128, 1181-8. PMID: 10578130 3. Villar, VA. et al. (2009) The Journal of biological chemistry 284, 21425-34. PMID: 19520868 4. Barroso-Chinea, P. et al. (2020) Autophagy 16, 1279-1295. PMID: 31538542 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Mouse IgG2a Recombinant Isotype Control Antibody (S43.10) (MF533307) |
SEC-HPLC detection for Anti-Human DRD3 Antibody (N331/19).
SDS-PAGE for Anti-Human DRD3 Antibody (N331/19).
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