

| Número de catálogo | HD149014 | ||||||||
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| Descripción |
Anti-Human DXO Polyclonal Antibody (HD149014) is a rabbit polyclonal antibody detecting DXO. Suitable for Human, Mouse, and Rat.
Highlights
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| Reactividad de especies | Human, Mouse, Rat | ||||||||
| Aplicaciones | ELISA, IHC, WB | ||||||||
| Especie huésped | Rabbit | ||||||||
| Clonalidad | Polyclonal | ||||||||
| Isotipo | IgG | ||||||||
| Inmunógeno | E. coli - derived recombinant Human DXO (Thr31-Lys396). | ||||||||
| Objetivo | 5'-3' exoribonuclease DXO, DOM3L, DOM3Z, DXO, DeNADding enzyme DXO, Decapping and exoribonuclease protein, Dom-3 homolog Z, EC:3.1.13.-, EC:3.6.1.-, NAD-capped RNA hydrolase DXO, NG6 | ||||||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||||||
| Purificación | Purified by antigen affinity column. | ||||||||
| Número de acceso | O77932 | ||||||||
| Forma | Liquid | ||||||||
| Buffer de almacenamiento | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Fondo | Decapping and exoribonuclease protein (DXO) is a ~44 kDa protein. Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA. The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to environmental stress. Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation. 1. Jiao, X. et al. (2017) Cell 168, 1015-1027.e10. PMID: 28283058 2. Grudzien-Nogalska, E. et al. (2019) Nature chemical biology 15, 575-582. PMID: 31101919 3. Picard-Jean, F. et al. (2018) PloS one 13, e0193804. PMID: 29601584 4. Doamekpor, SK. et al. (2020) Nucleic acids research 48, 6136-6148. PMID: 32374864 | ||||||||
| Nota | For research use only |
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