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| カタログ番号 | HB967014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human EIF2S2 Polyclonal Antibody (HB967014) is a rabbit polyclonal antibody detecting EIF2S2 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EIF2S2 (Gln208-Asn333). | ||||||||
| ターゲット | Eukaryotic translation initiation factor 2 subunit 2, Eukaryotic translation initiation factor 2 subunit beta, EIF2S2, eIF-2-beta, EIF2B | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P20042 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2) is a ~38 kDa protein. Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. 1. Young-Baird, SK. et al. (2020) Molecular cell 77, 875-886.e7. PMID: 31836389 | ||||||||
| 注意事項 | For research use only. |
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