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| カタログ番号 | HC232014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human EIF3A Polyclonal Antibody (HC232014) is a rabbit polyclonal antibody detecting EIF3A. Suitable for Rat, Mouse, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EIF3A (Met1-Arg520). | ||||||||
| ターゲット | EIF3A, EIF3S10, Eukaryotic translation initiation factor 3 subunit 10, Eukaryotic translation initiation factor 3 subunit A, KIAA0139, eIF-3-theta, eIF3 p167, eIF3 p180, eIF3 p185, eIF3a | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q14152 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Eukaryotic translation initiation factor 3 subunit A (EIF3A) is a ~166 kDa protein. RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. 1. Masutani, M. et al. (2007) The EMBO journal 26, 3373-83. PMID: 17581632 2. Lee, AS. et al. (2015) Nature 522, 111-4. PMID: 25849773 3. Lin, L. et al. (2001) Journal of cellular biochemistry 80, 483-90. PMID: 11169732 4. Lee, AS. et al. (2016) Nature 536, 96-9. PMID: 27462815 | ||||||||
| 注意事項 | For research use only |
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