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| カタログ番号 | HT496014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human EIF3D Polyclonal Antibody (HT496014) is a rabbit polyclonal antibody detecting eIF3d in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EIF3D (Ser166-Ser521). | ||||||||
| ターゲット | eIF3 p66, Eukaryotic translation initiation factor 3 subunit 7, eIF3d, EIF3D, EIF3S7, Eukaryotic translation initiation factor 3 subunit D, eIF-3-zeta | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15371 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Eukaryotic translation initiation factor 3 subunit D (EIF3D) is a ~63 kDa protein. mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, a complex required for several steps in the initiation of protein synthesis of a specialized repertoire of mRNAs. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. 1. Lee, AS. et al. (2016) Nature 536, 96-9. PMID: 27462815 2. Zhou, M. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 18139-44. PMID: 18599441 3. Lee, AS. et al. (2015) Nature 522, 111-4. PMID: 25849773 | ||||||||
| 注意事項 | For research use only. |
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