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| カタログ番号 | HT124014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human EIF4E2 Polyclonal Antibody (HT124014) is a rabbit polyclonal antibody detecting EIF4E2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EIF4E2 (Glu53-Pro245). | ||||||||
| ターゲット | Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3, EIF4E2, EIF4EL3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O60573 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Eukaryotic translation initiation factor 4E type 2 (EIF4E2) is a ~28 kDa protein. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation. Acts as a repressor of translation initiation. In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap. In P-bodies, component of a complex that promotes miRNA-mediated translational repression. Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism. 1. Rosettani, P. et al. (2007) Journal of molecular biology 368, 691-705. PMID: 17368478 2. Morita, M. et al. (2012) Molecular and cellular biology 32, 3585-93. PMID: 22751931 3. von Stechow, L. et al. (2015) Molecular and cellular biology 35, 1254-68. PMID: 25624349 4. Zhang, X. et al. (2021) Molecular cell 81, 1187-1199.e5. PMID: 33581076 5. Rom, E. et al. (1998) The Journal of biological chemistry 273, 13104-9. PMID: 9582349 6. Chapat, C. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, 5425-5430. PMID: 28487484 | ||||||||
| 注意事項 | For research use only. |
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