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| カタログ番号 | HX091014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EIF6 (Met1-Thr245). | ||||||||
| ターゲット | Eukaryotic translation initiation factor 6, EIF3A, eIF-6, ITGB4BP, B(2)GCN homolog, B4 integrin interactor, CAB, p27(BBP), EIF6 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P56537 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Eukaryotic translation initiation factor 6 (EIF6) is a ~26 kDa protein. Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. 1. Sanvito, F. et al. (1999) The Journal of cell biology 144, 823-37. PMID: 10085284 2. Ceci, M. et al. (2003) Nature 426, 579-84. PMID: 14654845 3. Finch, AJ. et al. (2011) Genes & development 25, 917-29. PMID: 21536732 4. Liang, X. et al. (2020) Nature communications 11, 3542. PMID: 32669547 5. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929 | ||||||||
| 注意事項 | For research use only. |
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