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| カタログ番号 | HP872013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1827 | ||||
| ターゲット | Hematopoietic signal peptide-containing membrane domain-containing protein 1, EMC10, INM02, C19orf63, ER membrane protein complex subunit 10 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q5UCC4 | ||||
| RRID | Anti-Human EMC10 Antibody (SAA1827) (abinScience Cat# HP872013, RRID:AB_3727590) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | ER membrane protein complex subunit 10 (EMC10) is a ~27 kDa protein. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. 1. Guna, A. et al. (2018) Science (New York, N.Y.) 359, 470-473. PMID: 29242231 2. Shurtleff, MJ. et al. (2018) eLife 7. PMID: 29809151 3. Chitwood, PJ. et al. (2018) Cell 175, 1507-1519.e16. PMID: 30415835 4. Pleiner, T. et al. (2020) Science (New York, N.Y.) 369, 433-436. PMID: 32439656 5. O'Donnell, JP. et al. (2020) eLife 9. PMID: 32459176 6. Reboll, MR. et al. (2017) Circulation 136, 1809-1823. PMID: 28931551 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human EMC10 Antibody (SAA1827)
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