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| カタログ番号 | HF787014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ENTPD5 Polyclonal Antibody (HF787014) is a rabbit polyclonal antibody detecting ENTPD5 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ENTPD5 (Asn25-His428). | ||||||||
| ターゲット | Nucleoside diphosphate phosphatase ENTPD5, 3.6.1.6, CD39 antigen-like 4, ER-UDPase, Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Inosine diphosphate phosphatase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75356 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Nucleoside diphosphate phosphatase ENTPD5 is a ~47 kDa protein. Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER. 1. Mulero, JJ. et al. (1999) The Journal of biological chemistry 274, 20064-7. PMID: 10400613 2. Murphy-Piedmonte, DM. et al. (2005) Biochimica et biophysica acta 1747, 251-9. PMID: 15698960 | ||||||||
| 注意事項 | For research use only. |
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