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| カタログ番号 | HC510013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA, IF, IP, IP-MS | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, kappa | ||||
| クローンID | SAA0246 | ||||
| ターゲット | Histone crotonyltransferase p300, Protein lactyltransferas p300, Protein propionyltransferase p300, Histone acetyltransferase p300, Protein 2-hydroxyisobutyryltransferase p300, EP300, p300 HAT, Histone butyryltransferase p300, P300, E1A-associated protein p300 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | Q09472 | ||||
| RRID | Anti-Human EP300 IP Antibody (SAA0246) (abinScience Cat# HC510013, RRID:AB_3729780) |
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| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Histone acetyltransferase p300 (EP300) is a ~264 kDa protein. Functions as a histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-18' and 'Lys-27' (H3K18ac and H3K27ac, respectively). 1. Tropberger, P. et al. (2013) Cell 152, 859-72. PMID: 23415232 2. Delvecchio, M. et al. (2013) Nature structural & molecular biology 20, 1040-6. PMID: 23934153 3. Tian, Y. et al. (2025) Nature 641, 779-787. PMID: 40240600 4. Ogryzko, VV. et al. (1996) Cell 87, 953-9. PMID: 8945521 5. Jin, Q. et al. (2011) The EMBO journal 30, 249-62. PMID: 21131905 6. Hatzi, K. et al. (2013) Cell reports 4, 578-88. PMID: 23911289 8. Iioka, T. et al. (2003) Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 18, 1419-29. PMID: 12929931 9. Yuan, ZL. et al. (2005) Science (New York, N.Y.) 307, 269-73. PMID: 15653507 10. Ray, S. et al. (2005) Gastroenterology 129, 1616-32. PMID: 16285960 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human EP300 IP Antibody (SAA0246)
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