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| カタログ番号 | HY479014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human EPRS1 Polyclonal Antibody (HY479014) is a rabbit polyclonal antibody detecting EPRS1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human EPRS1 (Asp749-Thr956). | ||||||||
| ターゲット | EPRS1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P07814 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 別名 | Bifunctional glutamate/proline--tRNA ligase, Bifunctional aminoacyl-tRNA synthetase, Cell proliferation-inducing gene 32 protein, Glutamatyl-prolyl-tRNA synthetase, Glutamate--tRNA ligase, 6.1.1.17, Glutamyl-tRNA synthetase, GluRS, Proline--tRNA ligase, 6.1.1.15, Prolyl-tRNA synthetase, EPRS1, EPRS, GLNS, PARS, QARS, QPRS, PIG32 | ||||||||
| 背景 | Bifunctional glutamate/proline--tRNA ligase (EPRS1) is a ~170 kDa protein. Multifunctional protein which primarily functions within the aminoacyl-tRNA synthetase multienzyme complex, also known as multisynthetase complex. Within the complex it catalyzes the attachment of both L-glutamate and L-proline to their cognate tRNAs in a two-step reaction where the amino acid is first activated by ATP to form a covalent intermediate with AMP. Subsequently, the activated amino acid is transferred to the acceptor end of the cognate tRNA to form L-glutamyl-tRNA(Glu) and L-prolyl-tRNA(Pro). Upon interferon-gamma stimulation, EPRS1 undergoes phosphorylation, causing its dissociation from the aminoacyl-tRNA synthetase multienzyme complex. It is recruited to form the GAIT complex, which binds to stem loop-containing GAIT elements found in the 3'-UTR of various inflammatory mRNAs, such as ceruloplasmin. 1. Zhou, H. et al. (2013) Nature 494, 121-4. PMID: 23263184 2. Son, J. et al. (2013) Acta crystallographica. Section D, Biological crystallography 69, 2136-45. PMID: 24100331 3. Mendes, MI. et al. (2018) American journal of human genetics 102, 676-684. PMID: 29576217 4. Thömmes, P. et al. (1988) Nucleic acids research 16, 5391-406. PMID: 3290852 5. Yoon, I. et al. (2023) EMBO molecular medicine 15, e16940. PMID: 37212275 6. Sampath, P. et al. (2004) Cell 119, 195-208. PMID: 15479637 7. Arif, A. et al. (2012) Molecular and cellular biology 32, 5046-55. PMID: 23071094 8. Arif, A. et al. (2017) Nature 542, 357-361. PMID: 28178239 | ||||||||
| 注意事項 | For research use only. |
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