

| Número de catálogo | HS700023 | ||||
|---|---|---|---|---|---|
| Descripción |
Anti-Human ERFE Recombinant Antibody (SAA2375) (HS700023) is a mouse monoclonal antibody detecting ERFE in ELISA. Suitable for Human.
Highlights
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| Reactividad de especies | Human | ||||
| Aplicaciones | ELISA | ||||
| Especie huésped | Mouse | ||||
| Clonalidad | Monoclonal | ||||
| Isotipo | IgG2a, kappa | ||||
| ID de clon | SAA2375 | ||||
| Objetivo | Erythroferrone, Complement C1q tumor necrosis factor-related protein 15, Myonectin, ERFE, C1QTNF15, CTRP15, FAM132B | ||||
| Nivel de endotoxinas | < 10 EU/mg as determined by LAL method. | ||||
| Pureza | >95% as determined by SDS-PAGE. | ||||
| Purificación | Protein A/G purified from cell culture supernatant. | ||||
| Número de acceso | Q4G0M1 | ||||
| Forma | Liquid | ||||
| Buffer de almacenamiento | 0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Fondo | Erythroferrone (ERFE) is a ~37 kDa protein. Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling. Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway. Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling. 1. Kautz, L. et al. (2014) Nature genetics 46, 678-84. PMID: 24880340 2. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509 3. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957 | ||||
| Nota | For research use only. | ||||
| Isotype Control | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507) |

SDS-PAGE for Anti-Human ERFE Antibody (SAA2375)



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