Anti-Human ERFE Recombinant Antibody (SAA2375) (HS700023)

Name: Anti-Human ERFE Recombinant Antibody (SAA2375)
Brand: abinScience
SKU: HS700023
Price: 191 USD
Availability: InStock

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Spécification :

50ug
100ug
1mg

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HS700023

Description

Anti-Human ERFE Recombinant Antibody (SAA2375) (HS700023) is a mouse monoclonal antibody detecting ERFE in ELISA. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.

Reactivité des espèces

Human

Applications

ELISA

Espèce hôte

Mouse

Clonalité

Monoclonal

Isotype

IgG2a, kappa

ID de clone

SAA2375

Cible

Erythroferrone, Complement C1q tumor necrosis factor-related protein 15, Myonectin, ERFE, C1QTNF15, CTRP15, FAM132B

Niveau d'endotoxines

< 10 EU/mg as determined by LAL method.

Pureté

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

Q4G0M1

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Erythroferrone (ERFE) is a ~37 kDa protein. Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores. Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake. Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling. Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway. Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling.

1. Kautz, L. et al. (2014) Nature genetics 46, 678-84. PMID: 24880340

2. Arezes, J. et al. (2018) Blood 132, 1473-1477. PMID: 30097509

3. Wang, CY. et al. (2020) Blood 135, 453-456. PMID: 31800957

Note

For research use only.

Isotype Control

Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

Images

SDS-PAGE

SDS-PAGE for Anti-Human ERFE Antibody (SAA2375)

Reférences

Fiche technique

Anti-Human ERFE Recombinant Antibody (SAA2375).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

Kits d'Essai

Anti-Human ERFE Recombinant Antibody (SAA2375) (HS700023)

Aperçu

Images

Reférences

Fiche technique

SDS