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| カタログ番号 | HF518014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ERLIN1 Polyclonal Antibody (HF518014) is a rabbit polyclonal antibody detecting ERLIN1 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ERLIN1 (Glu29-Thr173). | ||||||||
| ターゲット | SPFH1, SPFH domain-containing protein 1, Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1, C10orf69, KEO4, Protein KE04, Endoplasmic reticulum lipid raft-associated protein 1, ERLIN1, Erlin-1, KE04 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O75477 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Erlin-1 (ERLIN1) is a ~39 kDa protein. Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex. 1. Teo, QW. et al. (2023) Developmental cell 58, 2495-2509.e6. PMID: 37683630 2. Huber, MD. et al. (2013) The Journal of cell biology 203, 427-36. PMID: 24217618 | ||||||||
| 注意事項 | For research use only. |
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