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| カタログ番号 | HF928014 | ||||||||
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| 説明 |
Anti-Human ESRRB Polyclonal Antibody (HF928014) is a rabbit polyclonal antibody detecting ESRRB in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ESRRB (Gly235-Val433). | ||||||||
| ターゲット | ERR-beta, NR3B2, Estrogen-related receptor beta, ESRL2, Estrogen receptor-like 2, ERR beta-2, ESRRB, Nuclear receptor subfamily 3 group B member 2, Steroid hormone receptor ERR2, ERRB2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95718 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Steroid hormone receptor ERR2 (ESRRB) is a ~48 kDa protein. Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity. Plays a role, in a LIF-independent manner, in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Involved in morula development (2-16 cells embryos) by acting as a regulator at the 8-cell stage. Upon FGF signaling pathway activation, interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type. 1. Zhou, W. et al. (2007) Molecular and cellular endocrinology 278, 52-62. PMID: 17920186 2. Bombail, V. et al. (2010) Molecular and cellular endocrinology 314, 53-61. PMID: 19755138 3. Cho, Y. et al. (2013) The Journal of biological chemistry 288, 25207-25218. PMID: 23836911 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-ESRRB polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse heart lysate
Lane 2: Rat heart lysate
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