中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HD118014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human ETF1 Polyclonal Antibody (HD118014) is a rabbit polyclonal antibody detecting ETF1. Suitable for Human, Mouse, and Rat.
Highlights
|
||||||||
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ETF1 (Met1-Ser257). | ||||||||
| ターゲット | ERF1, ETF1, Eukaryotic peptide chain release factor subunit 1, Eukaryotic release factor 1, Protein Cl1, RF1, SUP45L1, TB3-1, eRF1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P62495 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 背景 | Eukaryotic peptide chain release factor subunit 1 (ETF1) is a ~49 kDa protein. Component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons. The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. ETF1/ERF1 is responsible for stop codon recognition and inducing hydrolysis of peptidyl-tRNA. Following GTP hydrolysis, eRF3 (GSPT1/ERF3A or GSPT2/ERF3B) dissociates, permitting ETF1/eRF1 to accommodate fully in the A-site and mediate hydrolysis of peptidyl-tRNA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. 1. Song, H. et al. (2000) Cell 100, 311-21. PMID: 10676813 2. Alkalaeva, EZ. et al. (2006) Cell 125, 1125-36. PMID: 16777602 3. Feng, T. et al. (2014) Molecular cell 53, 645-54. PMID: 24486019 4. Brown, A. et al. (2015) Nature 524, 493-496. PMID: 26245381 5. Shao, S. et al. (2016) Cell 167, 1229-1240.e15. PMID: 27863242 6. Oltion, K. et al. (2023) Cell 186, 346-362.e17. PMID: 36638793 7. Frolova, L. et al. (1994) Nature 372, 701-3. PMID: 7990965 8. Yamashita, A. et al. (2009) Genes & development 23, 1091-105. PMID: 19417104 9. Wang, X. et al. (2019) Cell 176, 625-635.e14. PMID: 30682371 | ||||||||
| 注意事項 | For research use only |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
