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Anti-Human EXTL3 Polyclonal Antibody (HD524014)

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Aperçu
Numéro de catalogueHD524014
Description
Anti-Human EXTL3 Polyclonal Antibody (HD524014) is a rabbit polyclonal antibody detecting EXTL3. Suitable for Human and Mouse.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Reactivité des espècesHuman, Mouse
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human EXTL3 (Tyr341-Ile540).
Cible EC:2.4.1.223, EXT-related protein 1, EXTL1L, EXTL3, EXTR1, Exostosin-like 3, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Hereditary multiple exostoses gene isolog, KIAA0519, Multiple exostosis-like protein 3, Putative tumor suppressor protein EXTL3
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès O43909
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Exostosin-like 3 (EXTL3) is a ~104 kDa protein. Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs).

1. Oud, MM. et al. (2017) American journal of human genetics 100, 281-296. PMID: 28132690
2. Volpi, S. et al. (2017) The Journal of experimental medicine 214, 623-637. PMID: 28148688
3. Kim, BT. et al. (2001) Proceedings of the National Academy of Sciences of the United States of America 98, 7176-81. PMID: 11390981
4. Wilson, LFL. et al. (2022) Nature communications 13, 3314. PMID: 35676258
5. Lai, Y. et al. (2012) Immunity 37, 74-84. PMID: 22727489
Note For research use only
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
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