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| カタログ番号 | HP606014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FA2H Polyclonal Antibody (HP606014) is a rabbit polyclonal antibody detecting FA2H in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FA2H (Ser12-Arg86). | ||||||||
| ターゲット | Fatty acid 2-hydroxylase, Fatty acid alpha-hydroxylase, FAXDC1, FAAH, FA2H, Fatty acid hydroxylase domain-containing protein 1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q7L5A8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Fatty acid 2-hydroxylase (FA2H) is a ~42 kDa protein. Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. 1. Alderson, NL. et al. (2004) The Journal of biological chemistry 279, 48562-8. PMID: 15337768 2. Alderson, NL. et al. (2005) Journal of lipid research 46, 1569-75. PMID: 15863841 3. Uchida, Y. et al. (2007) The Journal of biological chemistry 282, 13211-9. PMID: 17355976 4. Guo, L. et al. (2012) Journal of lipid research 53, 1327-35. PMID: 22517924 | ||||||||
| 注意事項 | For research use only. |
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