

| Каталожный номер | HD694014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human FAAH Polyclonal Antibody (HD694014) is a rabbit polyclonal antibody detecting FAAH. Suitable for Human.
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human FAAH (Ser71-Ser579). | ||||||||
| Цель | Anandamide amidohydrolase 1, EC:3.1.1.-, EC:3.5.1.99, FAAH, FAAH1, Fatty acid ester hydrolase, Fatty-acid amide hydrolase 1, Oleamide hydrolase 1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O00519 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Фон | Fatty-acid amide hydrolase 1 (FAAH) is a ~63 kDa protein. Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates. It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids. 1. Wei, BQ. et al. (2006) The Journal of biological chemistry 281, 36569-78. PMID: 17015445 2. Kaczocha, M. et al. (2010) The Journal of biological chemistry 285, 2796-806. PMID: 19926788 3. Giang, DK. et al. (1997) Proceedings of the National Academy of Sciences of the United States of America 94, 2238-42. PMID: 9122178 4. Xie, S. et al. (2010) Chemical research in toxicology 23, 1890-904. PMID: 21049984 | ||||||||
| Примечание | For research use only |
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