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| カタログ番号 | HT042013 | ||||
|---|---|---|---|---|---|
| 種反応性 | Human | ||||
| アプリケーション | ELISA | ||||
| 宿主種 | Mouse | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2a, kappa | ||||
| クローンID | SAA1792 | ||||
| ターゲット | D5D, FADS1, Delta(5) fatty acid desaturase, Acyl-CoA (8-3)-desaturase, Fatty acid desaturase 1, Delta(5) desaturase, Delta-5 desaturase, FADSD5 | ||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | O60427 | ||||
| RRID | Anti-Human FADS1/Delta 5 desaturase Antibody (SAA1792) (abinScience Cat# HT042013, RRID:AB_3727554) |
||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||
| 背景 | Acyl-CoA (8-3)-desaturase (FADS1/Delta 5 desaturase) is a ~51 kDa protein. Acts as a front-end fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 5 located between a preexisting double bond and the carboxyl end of the fatty acyl chain. Involved in biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors. Specifically, desaturates dihomo-gamma-linoleoate (DGLA) (20:3n-6) and eicosatetraenoate (ETA) (20:4n-3) to generate arachidonate (AA) (20:4n-6) and eicosapentaenoate (EPA) (20:5n-3), respectively. As a rate limiting enzyme for DGLA (20:3n-6) and AA (20:4n-6)-derived eicosanoid biosynthesis, controls the metabolism of inflammatory lipids like prostaglandin E2, critical for efficient acute inflammatory response and maintenance of epithelium homeostasis. Contributes to membrane phospholipid biosynthesis by providing AA (20:4n-6) as a major acyl chain esterified into phospholipids. 1. Cho, HP. et al. (1999) The Journal of biological chemistry 274, 37335-9. PMID: 10601301 2. Leonard, AE. et al. (2000) The Biochemical journal 347 Pt 3, 719-24. PMID: 10769175 | ||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human FADS1/Delta 5 desaturase Antibody (SAA1792)
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