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| カタログ番号 | HA265014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FANCM Polyclonal Antibody (HA265014) is a rabbit polyclonal antibody detecting FANCM in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FANCM (Ser281-His620). | ||||||||
| ターゲット | Fanconi anemia group M protein, Protein FACM, 3.6.4.13, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog, FANCM, KIAA1596 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8IYD8 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Fanconi anemia group M protein (FANCM) is a ~232 kDa protein. DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. 1. Meetei, AR. et al. (2005) Nature genetics 37, 958-63. PMID: 16116422 2. Singh, TR. et al. (2009) Blood 114, 174-80. PMID: 19423727 3. Yan, Z. et al. (2010) Molecular cell 37, 865-78. PMID: 20347428 4. Singh, TR. et al. (2010) Molecular cell 37, 879-86. PMID: 20347429 5. Fouquet, B. et al. (2017) eLife 6. PMID: 29231814 6. Ciccia, A. et al. (2007) Molecular cell 25, 331-43. PMID: 17289582 | ||||||||
| 注意事項 | For research use only. |
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