Anti-Human FANCM Polyclonal Antibody (HA265014)

Name: Anti-Human FANCM Polyclonal Antibody
Brand: abinScience
SKU: HA265014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HA265014

Описание

Anti-Human FANCM Polyclonal Antibody (HA265014) is a rabbit polyclonal antibody detecting FANCM in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human FANCM (Ser281-His620).

Цель

Fanconi anemia group M protein, Protein FACM, 3.6.4.13, ATP-dependent RNA helicase FANCM, Fanconi anemia-associated polypeptide of 250 kDa, FAAP250, Protein Hef ortholog, FANCM, KIAA1596

Очистка

Purified by antigen affinity column.

Номер доступа

Q8IYD8

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Fanconi anemia group M protein (FANCM) is a ~232 kDa protein. DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX.

1. Meetei, AR. et al. (2005) Nature genetics 37, 958-63. PMID: 16116422

2. Singh, TR. et al. (2009) Blood 114, 174-80. PMID: 19423727

3. Yan, Z. et al. (2010) Molecular cell 37, 865-78. PMID: 20347428

4. Singh, TR. et al. (2010) Molecular cell 37, 879-86. PMID: 20347429

5. Fouquet, B. et al. (2017) eLife 6. PMID: 29231814

6. Ciccia, A. et al. (2007) Molecular cell 25, 331-43. PMID: 17289582

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-Human FANCM Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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