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| カタログ番号 | HP533014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FBXO22 (Arg61-Lys403). | ||||||||
| ターゲット | FBX22, F-box protein FBX22p44, FBXO22, F-box only protein 22 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q8NEZ5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | F-box only protein 22 (FBXO22) is a ~44 kDa protein. Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that is implicated in the control of various cellular processes such as cell cycle control, transcriptional regulation, DNA damage repair, and apoptosis. Promotes the proteasome-dependent degradation of key sarcomeric proteins, such as alpha-actinin (ACTN2) and filamin-C (FLNC), essential for maintenance of normal contractile function. Acts as a key regulator of histone methylation marks namely H3K9 and H3K36 methylation through the regulation of histone demethylase KDM4A protein levels. In complex with KDM4A, also regulates the abundance of TP53 by targeting methylated TP53 for degradation at the late senescent stage. Under oxidative stress, promotes the ubiquitination and degradation of BACH1. 1. Tan, MK. et al. (2011) Molecular and cellular biology 31, 3687-99. PMID: 21768309 2. Johmura, Y. et al. (2016) Nature communications 7, 10574. PMID: 26868148 3. Cao, S. et al. (2024) Cell 187, 7568-7584.e22. PMID: 39504958 4. Ge, MK. et al. (2023) Cell metabolism 35, 2216-2230.e8. PMID: 37979583 5. Zhou, Y. et al. (2024) Journal of medical virology 96, e29891. PMID: 39223933 | ||||||||
| 注意事項 | For research use only. |
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