Anti-Human FCRN/FCGRT Recombinant Antibody (SAA0135), PE (HX061127)

Name: Anti-Human FCRN/FCGRT Recombinant Antibody (SAA0135), PE
Brand: abinScience
SKU: HX061127
Price: 290 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HX061127
種反応性	Human
アプリケーション	FCM
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG4, kappa
クローンID	SAA0135
抱合	PE
ターゲット	IgG Fc fragment receptor transporter alpha chain, IgG receptor FcRn large subunit p51, FcRn, FCGRT, FCRN, Neonatal Fc receptor
エンドトキシンレベル	Please contact with the lab for this information.
関連製品	Human IgG4 (S228P) Recombinant Isotype Control Antibody (13R4), PE
アクセッション番号	P55899
形態	Liquid
保存バッファー	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Store at 4°C for 12 months. Protect from light. Do not freeze.
背景	IgG receptor FcRn large subunit p51 (FCGRT) is a ~39 kDa protein. Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. 1. West, AP. et al. (2000) Biochemistry 39, 9698-708. PMID: 10933786 2. Story, CM. et al. (1994) The Journal of experimental medicine 180, 2377-81. PMID: 7964511 3. Mikulska, JE. et al. (2000) European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics 27, 231-40. PMID: 10998088 4. Oganesyan, V. et al. (2014) The Journal of biological chemistry 289, 7812-24. PMID: 24469444 5. Pyzik, M. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E2862-E2871. PMID: 28330995
注意事項	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.