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| カタログ番号 | HT129014 | ||||||||
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| 説明 |
Anti-Human FCHO1 Polyclonal Antibody (HT129014) is a rabbit polyclonal antibody detecting FCHO1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FCHO1 (Ser616-Cys889). | ||||||||
| ターゲット | F-BAR domain only protein 1, FCHO1, KIAA0290 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14526 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | F-BAR domain only protein 1 (FCHO1) is a ~96 kDa protein. Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation. 1. Calzoni, E. et al. (2019) The Journal of allergy and clinical immunology 143, 2317-2321.e12. PMID: 30822429 2. Łyszkiewicz, M. et al. (2020) Nature communications 11, 1031. PMID: 32098969 | ||||||||
| 注意事項 | For research use only. |
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