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Anti-Human FCN2 Polyclonal Antibody (HS794014)

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Aperçu
Numéro de catalogueHS794014
Description
Anti-Human FCN2 Polyclonal Antibody (HS794014) is a rabbit polyclonal antibody detecting FCN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human FCN2 (Thr47-Asn300).
Cible Hucolin, FCNL, Collagen/fibrinogen domain-containing protein 2, 37 kDa elastin-binding protein, Serum lectin p35, Ficolin-2, EBP-37, FCN2, Ficolin-beta, L-ficolin, Ficolin-B
Purification Purified by antigen affinity column.
Numéro d'accès Q15485
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Ficolin-2 (FCN2) is a ~34 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect.

1. Matsushita, M. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 2281-4. PMID: 10679061
2. Lynch, NJ. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 1198-202. PMID: 14707097
3. Kuraya, M. et al. (2005) Immunobiology 209, 689-97. PMID: 15804047
4. Garlatti, V. et al. (2007) The EMBO journal 26, 623-33. PMID: 17215869
5. Vassal-Stermann, E. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5699-708. PMID: 25344472
6. Matsushita, M. et al. (1996) The Journal of biological chemistry 271, 2448-54. PMID: 8576206
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human FCN2 Polyclonal Antibody

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