

| Каталожный номер | HS794014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-Human FCN2 Polyclonal Antibody (HS794014) is a rabbit polyclonal antibody detecting FCN2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human FCN2 (Thr47-Asn300). | ||||||||
| Цель | Hucolin, FCNL, Collagen/fibrinogen domain-containing protein 2, 37 kDa elastin-binding protein, Serum lectin p35, Ficolin-2, EBP-37, FCN2, Ficolin-beta, L-ficolin, Ficolin-B | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q15485 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Ficolin-2 (FCN2) is a ~34 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect. 1. Matsushita, M. et al. (2000) Journal of immunology (Baltimore, Md. : 1950) 164, 2281-4. PMID: 10679061 2. Lynch, NJ. et al. (2004) Journal of immunology (Baltimore, Md. : 1950) 172, 1198-202. PMID: 14707097 3. Kuraya, M. et al. (2005) Immunobiology 209, 689-97. PMID: 15804047 4. Garlatti, V. et al. (2007) The EMBO journal 26, 623-33. PMID: 17215869 5. Vassal-Stermann, E. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 193, 5699-708. PMID: 25344472 6. Matsushita, M. et al. (1996) The Journal of biological chemistry 271, 2448-54. PMID: 8576206 | ||||||||
| Примечание | For research use only. |
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