Anti-Human FLCN Polyclonal Antibody (HP707014)

Name: Anti-Human FLCN Polyclonal Antibody
Brand: abinScience
SKU: HP707014
Price: 168 USD
Availability: InStock

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Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HP707014

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human FLCN (Lys347-Asn579).

Objetivo

BHD skin lesion fibrofolliculoma protein, FLCN, Birt-Hogg-Dube syndrome protein, BHD, Folliculin

Purificación

Purified by antigen affinity column.

Número de acceso

Q8NFG4

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Folliculin (FLCN) is a ~64 kDa protein. Multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis. GTPase-activating protein that plays a key role in the cellular response to amino acid availability through regulation of the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3. Activates mTORC1 by acting as a GTPase-activating protein: specifically stimulates GTP hydrolysis by RagC/RRAGC or RagD/RRAGD, promoting the conversion to the GDP-bound state of RagC/RRAGC or RagD/RRAGD, and thereby activating the kinase activity of mTORC1. The GTPase-activating activity is inhibited during starvation and activated in presence of nutrients. Acts as a key component for non-canonical mTORC1-dependent control of the MiT/TFE factors TFEB and TFE3, while it is not involved in mTORC1-dependent phosphorylation of canonical RPS6KB1/S6K1 and EIF4EBP1/4E-BP1.

1. Baba, M. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 15552-7. PMID: 17028174

2. Takagi, Y. et al. (2008) Oncogene 27, 5339-47. PMID: 18663353

3. Hong, SB. et al. (2010) PloS one 5, e15793. PMID: 21209915

4. Petit, CS. et al. (2013) The Journal of cell biology 202, 1107-22. PMID: 24081491

5. Tsun, ZY. et al. (2013) Molecular cell 52, 495-505. PMID: 24095279

6. Lawrence, RE. et al. (2019) Science (New York, N.Y.) 366, 971-977. PMID: 31672913

7. Shen, K. et al. (2019) Cell 179, 1319-1329.e8. PMID: 31704029

8. Napolitano, G. et al. (2020) Nature 585, 597-602. PMID: 32612235

9. Woodford, MR. et al. (2021) Nature structural & molecular biology 28, 662-670. PMID: 34381247

10. Jansen, RM. et al. (2022) Science advances 8, eadd2926. PMID: 36103527

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human FLCN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo