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Anti-Human FMO5 Polyclonal Antibody (HD536014)

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Aperçu
Numéro de catalogueHD536014
Description
Anti-Human FMO5 Polyclonal Antibody (HD536014) is a rabbit polyclonal antibody detecting FMO5. Suitable for Human.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human FMO5 (Met1-Ser512).
Cible Baeyer-Villiger monooxygenase 1, Dimethylaniline monooxygenase [N-oxide-forming] 5, Dimethylaniline oxidase 5, EC:1.14.13.-, EC:1.14.13.8, EC:1.6.3.1, FMO 5, FMO5, Flavin-containing monooxygenase 5, NADPH oxidase, hBVMO1
Niveau d'endotoxines Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Numéro d'accès P49326
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Contexte

Flavin-containing monooxygenase 5 (FMO5) is a ~60 kDa protein. Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline.

1. Lai, WG. et al. (2011) Drug metabolism and disposition: the biological fate of chemicals 39, 61-70. PMID: 20947616
2. Fiorentini, F. et al. (2016) ACS chemical biology 11, 1039-48. PMID: 26771671
3. Fiorentini, F. et al. (2017) ACS chemical biology 12, 2379-2387. PMID: 28783300
4. Overby, LH. et al. (1995) Archives of biochemistry and biophysics 317, 275-84. PMID: 7872795
Note For research use only
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Reférences
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Recommandation

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