



| Каталожный номер | HB825013 | ||||
|---|---|---|---|---|---|
| Описание |
Anti-Human FOLR1 Nanobody (SAA2048) [SAA2048] (HB825013) is a alpaca monoclonal antibody detecting FOLR1 in ELISA, FCM. Suitable for Human and Cynomolgus.
Highlights
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| Реактивность видов | Human, Cynomolgus | ||||
| Применения | ELISA, FCM | ||||
| Хозяинский вид | Alpaca | ||||
| Клоональность | Monoclonal | ||||
| Изотип | VHH-8His-Cys-tag | ||||
| ID клона | SAA2048 | ||||
| Цель | Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult | ||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||
| Чистота | >95% as determined by SDS-PAGE. | ||||
| Очистка | Purified by Nickel column. | ||||
| Номер доступа | P15328 | ||||
| Форма | Liquid | ||||
| Буфер хранения | 0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Фон | Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere). 1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442 2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396 3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049 4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252 5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114 6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728 | ||||
| Примечание | For research use only. |

SDS-PAGE for Anti-Human FOLR1 Nanobody (SAA2048)

Detects recombinant FOLR1 (Catalog No: HB825011) in indirect ELISA.




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