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Anti-Human FOLR1 Recombinant Nanobody (SAA2048)
Anti-Human FOLR1 Recombinant Nanobody (SAA2048)
Anti-Human FOLR1 Recombinant Nanobody (SAA2048)
Anti-Human FOLR1 Recombinant Nanobody (SAA2048)
Цена(USD):
Спецификация:
  • 20ug
  • 50ug
  • 100ug
  • 1mg
Количество:
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  • Обзор

  • Изображения

  • Ссылки

  • Даташит

  • SDS

Обзор
Каталожный номерHB825013
Описание
Anti-Human FOLR1 Nanobody (SAA2048) [SAA2048] (HB825013) is a alpaca monoclonal antibody detecting FOLR1 in ELISA, FCM. Suitable for Human and Cynomolgus.
Highlights
  • ●Flow Cytometry — Validated for flow cytometry applications.
Реактивность видовHuman, Cynomolgus
ПримененияELISA, FCM
Хозяинский видAlpaca
КлоональностьMonoclonal
ИзотипVHH-8His-Cys-tag
ID клонаSAA2048
Цель Folate receptor alpha, FOLR, FOLR1, Adult folate-binding protein, Folate receptor 1, FR-alpha, KB cells FBP, FBP, Ovarian tumor-associated antigen MOv18, Folate receptor, adult
Уровень эндотоксинов Please contact with the lab for this information.
Чистота >95% as determined by SDS-PAGE.
Очистка Purified by Nickel column.
Номер доступа P15328
Форма Liquid
Буфер хранения 0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта
Применение Разбавление
ELISA 1:2000-1:20000
Устойчивость и хранение Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон

Folate receptor alpha (FOLR1) is a ~29 kDa protein. Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. FOLR1 is the therapeutic target of mirvetuximab soravtansine (Elahere).

1. Zhao, R. et al. (2009) The Journal of biological chemistry 284, 4267-74. PMID: 19074442
2. Chen, C. et al. (2013) Nature 500, 486-9. PMID: 23851396
3. Wibowo, AS. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15180-8. PMID: 23934049
4. Lacey, SW. et al. (1989) The Journal of clinical investigation 84, 715-20. PMID: 2527252
5. Orr, RB. et al. (1994) Cancer research 54, 3905-11. PMID: 8033114
6. Rijnboutt, S. et al. (1996) The Journal of cell biology 132, 35-47. PMID: 8567728
Примечание For research use only.
Изображения
  • Anti-Human FOLR1 Recombinant Nanobody (SAA2048)

    SDS-PAGE

    SDS-PAGE for Anti-Human FOLR1 Nanobody (SAA2048)

  • Anti-Human FOLR1 Recombinant Nanobody (SAA2048)

    Bioactivity

    Detects recombinant FOLR1 (Catalog No: HB825011) in indirect ELISA.

Ссылки
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
Рекомендация

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Список дистрибьюторов