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| カタログ番号 | HD091014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FOSB Polyclonal Antibody (HD091014) is a rabbit polyclonal antibody detecting Protein FosB. Suitable for Rat, Mouse, and Human.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FOSB (Phe2-Leu338). | ||||||||
| ターゲット | FOSB, FosB proto-oncogene, AP-1 transcription factor subunit, G0/G1 switch regulatory protein 3, G0S3, Protein FosB, Transcription factor AP-1 subunit FosB | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P53539 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Protein FosB is a ~35 kDa protein. Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway. Exhibits transactivation activity in vitro. Involved in the display of nurturing behavior towards newborns. 1. Baumann, S. et al. (2003) Oncogene 22, 1333-9. PMID: 12618758 2. Yin, Z. et al. (2017) Nucleic acids research 45, 11425-11436. PMID: 28981703 | ||||||||
| 注意事項 | For research use only |
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