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| カタログ番号 | HV388013 | ||||||
|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||
| アプリケーション | ELISA, FCM, WB | ||||||
| 宿主種 | Mouse | ||||||
| クローン性 | Monoclonal | ||||||
| アイソタイプ | IgG1, kappa | ||||||
| クローンID | SAA1798 | ||||||
| ターゲット | Forkhead box protein P3, IPEX, Scurfin, FOXP3 | ||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||||
| アクセッション番号 | Q9BZS1 | ||||||
| RRID | Anti-Human FOXP3 Antibody (SAA1798) (abinScience Cat# HV388013, RRID:AB_3727560) |
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| 形態 | Liquid | ||||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. | ||||||
| 背景 | Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2. 1. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532 2. Bandukwala, HS. et al. (2011) Immunity 34, 479-91. PMID: 21458306 3. Vent-Schmidt, J. et al. (2014) International reviews of immunology 33, 110-28. PMID: 23947341 4. Passerini, L. et al. (2014) International reviews of immunology 33, 129-45. PMID: 24354325 5. Ramsdell, F. et al. (2014) Nature reviews. Immunology 14, 343-9. PMID: 24722479 6. Xiao, Y. et al. (2014) Cell reports 7, 1471-1480. PMID: 24835996 7. Becher, J. et al. (2018) Developmental cell 47, 592-607.e6. PMID: 30513302 8. Yang, J. et al. (2020) EMBO reports 21, e50308. PMID: 32644293 9. McMurchy, AN. et al. (2013) Blood 121, 1265-75. PMID: 23169781 10. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681 | ||||||
| 注意事項 | For research use only. |
SDS-PAGE for Anti-Human FOXP3 Antibody (SAA1798)
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