Anti-Human FoxP3 Recombinant Antibody (SAA1798) (HV388013)

Name: Anti-Human FoxP3 Recombinant Antibody (SAA1798)
Brand: abinScience
SKU: HV388013
Price: 191 USD
Availability: InStock

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Спецификация:

50ug
100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер

HV388013

Реактивность видов

Human

Применения

ELISA, FCM, WB

Хозяинский вид

Mouse

Клоональность

Monoclonal

Изотип

IgG1, kappa

ID клона

SAA1798

Цель

Forkhead box protein P3, IPEX, Scurfin, FOXP3

Уровень эндотоксинов

Please contact with the lab for this information.

Чистота

>95% as determined by SDS-PAGE.

Очистка

Protein A/G purified from cell culture supernatant.

Номер доступа

Q9BZS1

RRID

Anti-Human FOXP3 Antibody (SAA1798) (abinScience Cat# HV388013, RRID:AB_3727560)

Форма

Liquid

Буфер хранения

0.01M PBS pH 7.4

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:2000-1:20000
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Фон

Forkhead box protein P3 (FOXP3) is a ~47 kDa protein. Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2.

1. Ono, M. et al. (2007) Nature 446, 685-9. PMID: 17377532

2. Bandukwala, HS. et al. (2011) Immunity 34, 479-91. PMID: 21458306

3. Vent-Schmidt, J. et al. (2014) International reviews of immunology 33, 110-28. PMID: 23947341

4. Passerini, L. et al. (2014) International reviews of immunology 33, 129-45. PMID: 24354325

5. Ramsdell, F. et al. (2014) Nature reviews. Immunology 14, 343-9. PMID: 24722479

6. Xiao, Y. et al. (2014) Cell reports 7, 1471-1480. PMID: 24835996

7. Becher, J. et al. (2018) Developmental cell 47, 592-607.e6. PMID: 30513302

8. Yang, J. et al. (2020) EMBO reports 21, e50308. PMID: 32644293

9. McMurchy, AN. et al. (2013) Blood 121, 1265-75. PMID: 23169781

10. Bettelli, E. et al. (2005) Proceedings of the National Academy of Sciences of the United States of America 102, 5138-43. PMID: 15790681

Примечание

For research use only.

Изображения

SDS-PAGE

SDS-PAGE for Anti-Human FOXP3 Antibody (SAA1798)

Ссылки

Даташит

Anti-Human FoxP3 Recombinant Antibody (SAA1798).pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Рекомбинантные Белки

Антитела

Наборы для анализа