Anti-Human FYN Polyclonal Antibody (HC984014)

Name: Anti-Human FYN Polyclonal Antibody
Brand: abinScience
SKU: HC984014
Price: 168 USD
Availability: InStock

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Precio(USD): --

Especificación:

50ug
100ug

Número:

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Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HC984014

Descripción

Anti-Human FYN Polyclonal Antibody (HC984014) is a rabbit polyclonal antibody detecting FYN. Suitable for Human, Mouse, and Rat.

Highlights

●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human, Mouse, Rat

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human FYN (Thr85-Leu537).

Objetivo

EC:2.7.10.2, FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, Src-like kinase, Tyrosine-protein kinase Fyn, p59-Fyn

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

P06241

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Fondo

Tyrosine-protein kinase Fyn is a ~60 kDa protein. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT.

1. Wolf, RM. et al. (2001) Journal of neurobiology 49, 62-78. PMID: 11536198

2. Palacios, EH. et al. (2004) Oncogene 23, 7990-8000. PMID: 15489916

3. Meriane, M. et al. (2004) The Journal of cell biology 167, 687-98. PMID: 15557120

4. Yang, C. et al. (2006) Molecular cell 21, 135-41. PMID: 16387660

5. Goh, YM. et al. (2010) The Journal of biological chemistry 285, 10122-10129. PMID: 20100835

6. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 7568038

7. Rigley, K. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 1136-45. PMID: 7822789

8. Castaño, J. et al. (2007) Molecular and cellular biology 27, 1745-57. PMID: 17194753

Nota

For research use only

Imágenes

Western blot

Western blot analysis was performed using anti-FYN polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate

Referencias

Datasheet

Anti-Human FYN Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human FYN Polyclonal Antibody (HC984014)

Vista general

Imágenes

Referencias

Datasheet

SDS