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| カタログ番号 | HC984014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human FYN Polyclonal Antibody (HC984014) is a rabbit polyclonal antibody detecting FYN. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human FYN (Thr85-Leu537). | ||||||||
| ターゲット | EC:2.7.10.2, FYN, Proto-oncogene Syn, Proto-oncogene c-Fyn, SLK, Src-like kinase, Tyrosine-protein kinase Fyn, p59-Fyn | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P06241 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 背景 | Tyrosine-protein kinase Fyn is a ~60 kDa protein. Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. 1. Wolf, RM. et al. (2001) Journal of neurobiology 49, 62-78. PMID: 11536198 2. Palacios, EH. et al. (2004) Oncogene 23, 7990-8000. PMID: 15489916 3. Meriane, M. et al. (2004) The Journal of cell biology 167, 687-98. PMID: 15557120 4. Yang, C. et al. (2006) Molecular cell 21, 135-41. PMID: 16387660 5. Goh, YM. et al. (2010) The Journal of biological chemistry 285, 10122-10129. PMID: 20100835 6. Raab, M. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 8891-5. PMID: 7568038 7. Rigley, K. et al. (1995) Journal of immunology (Baltimore, Md. : 1950) 154, 1136-45. PMID: 7822789 8. Castaño, J. et al. (2007) Molecular and cellular biology 27, 1745-57. PMID: 17194753 | ||||||||
| 注意事項 | For research use only |
Western blot analysis was performed using anti-FYN polyclonal antibody at 1ug/mL on various samples.
Lane 1: Mouse brain lysate
Lane 2: Rat brain lysate
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