

| Número de catálogo | HC066023 | ||||
|---|---|---|---|---|---|
| Descripción |
Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319) [SAA2319] (HC066023) is a human monoclonal antibody detecting Frizzled-3 in ELISA. Suitable for Human.
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| Reactividad de especies | Human | ||||
| Aplicaciones | ELISA | ||||
| Especie huésped | Human | ||||
| Clonalidad | Monoclonal | ||||
| Isotipo | VHH-Fc | ||||
| ID de clon | SAA2319 | ||||
| Objetivo | Frizzled-3, Fz-3, hFz3, FZD3 | ||||
| Nivel de endotoxinas | Please contact with the lab for this information. | ||||
| Pureza | >95% as determined by SDS-PAGE. | ||||
| Purificación | Protein A/G purified from cell culture supernatant. | ||||
| Número de acceso | Q9NPG1 | ||||
| Forma | Liquid | ||||
| Buffer de almacenamiento | 0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Fondo | Frizzled-3 (FZD3) is a ~76 kDa protein. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. | ||||
| Nota | For research use only |

SDS-PAGE for Anti-Human FZD3/Frizzled-3 Nanobody (SAA2319)
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